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Understanding Bardet-Biedl Syndrome Hyperphagia: Intense, Hard-to-Control Hunger and its Impact


July 19, 2023


Explore hyperphagia, a prominent symptom of Bardet-Biedl syndrome characterized by intense, hard-to-control hunger. Understanding hyperphagia in Bardet-Biedl syndrome is crucial for effectively managing this challenging aspect of the condition. This article delves into the nature of hyperphagia, its impact on individuals with Bardet-Biedl syndrome, its role in weight gain, and strategies for managing this symptom.

Hyperphagia: Intense, Hard-to-Control Hunger in Bardet-Biedl Syndrome:

Hyperphagia is a symptom of Bardet-Biedl syndrome, presenting as intense, hard-to-control hunger. The feeling of hunger may be overwhelming – a deep hunger that can make it difficult to think about anything else – no matter the time of day, even right after meals. Hyperphagia typically starts in childhood and continues into adulthood. There are new resources, including an approved treatment, available for individuals living with hard-to-control hunger and obesity due to BBS.

Impact of Hyperphagia on Weight Gain in Bardet-Biedl Syndrome:

Hyperphagia significantly contributes to weight gain and obesity in individuals with Bardet-Biedl syndrome. The constant feeling of hunger and impaired satiety signals can lead to overconsumption of food, resulting in an imbalance between energy intake and expenditure. This excessive weight gain can negatively affect overall health. Recognizing the impact of hyperphagia on weight gain highlights the importance of management.

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Strategies for Managing Hyperphagia in Bardet-Biedl Syndrome:

Managing hyperphagia in Bardet-Biedl syndrome requires a comprehensive approach to care. Collaborating with a healthcare team, including an obesity specialist, is essential for care. Medical intervention may be necessary to address hyperphagia, which is a pathological disorder. Working with professionals can help individuals with Bardet-Biedl syndrome manage their hyperphagia and its impact on weight.


Hyperphagia, characterized by intense, hard-to-control hunger, is a significant symptom in individuals with Bardet-Biedl syndrome. Understanding the nature and impact of hyperphagia empowers healthcare providers and families pursue available treatment options. By addressing hyperphagia and its role in weight gain, we can enhance the overall well-being of individuals with Bardet-Biedl syndrome.


This blog post was developed by Ambit on behalf of Rhythm Pharmaceuticals, Inc.

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You are not alone. A community and a treatment for obesity in individuals living with BBS are out there – find out more today.

The majority of individuals living with BBS experience intense, hard-to-control hunger contributing to obesity. There is an approved treatment that significantly reduced measures of weight and hunger in clinical trials in people living with BBS. Take the questionnaire to connect to educational resources.

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Please note that AmbitCare provides this information for the benefit of the rare disease community. AmbitCare is not a medical provider nor a health care facility. AmbitCare can neither diagnose any disease or disorder nor endorse or recommend any specific medical treatments. Individuals must rely on the personal and individualized medical advice of their qualified health care professionals before seeking any information related to their particular diagnosis, cure, or treatment of a condition or disorder.