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Understanding the Link between Bardet-Biedl Syndrome and Obesity

AmbitCare

July 19, 2023

Explore the connection between Bardet-Biedl syndrome and obesity, understanding how this genetic disorder contributes to weight gain and the associated health implications. Learn about the underlying mechanisms, common obesity-related symptoms in individuals with Bardet-Biedl syndrome, and strategies for managing weight in this population.

Introduction:

Learn about the connection between Bardet-Biedl syndrome, a rare genetic condition that affects various body systems and obesity. This article explores how individuals with Bardet-Biedl syndrome experience severe, early-onset, rapid weight gain. Understanding the disease and treatments, available for individuals living with hard-to-control hunger and obesity due to BBS is essential for effective management.

Bardet-Biedl Syndrome and its Impact on Weight Regulation:

Bardet-Biedl syndrome affects genes involved in regulating appetite, metabolism, and energy balance. Malfunctioning of these genes disrupts the body’s ability to control hunger, resulting in excessive weight gain and obesity. Intense, hard-to-control hunger is a common experience for individuals with Bardet-Biedl syndrome, often leading to obesity and weight gain. Severe obesity can begin as early as a few months of age.

Symptoms and Health Implications of Obesity in Bardet-Biedl Syndrome:

Intense, hard-to-control hunger and obesity in individuals with Bardet-Biedl syndrome can have significant health implications. Excessive weight gain increases the risk of developing conditions like type 2 diabetes, hypertension, sleep apnea, and cardiovascular diseases. Obesity also worsens other aspects of the syndrome, including impaired glucose tolerance, dyslipidemia, and renal dysfunction. The excess weight can affect mobility, joint health, and overall quality of life. Monitoring and managing weight are crucial in reducing the risk of associated health complications and improving overall well-being.

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Managing Obesity in Bardet-Biedl Syndrome:

Intense, hard-to-control hunger and obesity due to BBS is unique and requires management. An obesity specialist and a multidisciplinary team can provide guidance and support. Treatments and medications are available to manage severe, hard-to-control hunger and obesity in individuals with Bardet-Biedl syndrome.

Conclusion:

Obesity is a significant aspect of Bardet-Biedl syndrome, impacting the health and well-being of individuals affected by this genetic disorder. Understanding the link between Bardet-Biedl syndrome and obesity allows healthcare providers and families to pursue treatment options for weight management. Addressing the underlying mechanisms and implementing appropriate interventions, individuals with Bardet-Biedl syndrome can help improve their overall health outcomes.

 

This blog post was developed by Ambit on behalf of Rhythm Pharmaceuticals, Inc.

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You are not alone. A community and a treatment for obesity in individuals living with BBS are out there – find out more today.

The majority of individuals living with BBS experience intense, hard-to-control hunger contributing to obesity. There is an approved treatment that significantly reduced measures of weight and hunger in clinical trials in people living with BBS. Take the questionnaire to connect to educational resources.

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Disclaimer

Please note that AmbitCare provides this information for the benefit of the rare disease community. AmbitCare is not a medical provider nor a health care facility. AmbitCare can neither diagnose any disease or disorder nor endorse or recommend any specific medical treatments. Individuals must rely on the personal and individualized medical advice of their qualified health care professionals before seeking any information related to their particular diagnosis, cure, or treatment of a condition or disorder.