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Learn About Rare Disease >    Lennox-Gastaut Syndrome (LGS)

Lennox-Gastaut Syndrome (LGS)

Lennox-Gastaut syndrome (LGS) is a rare form of epilepsy characterized by difficult to control seizures and a unique EEG pattern. There are many different causes of LGS including several genetic mutations.

Key characteristics and symptoms of Lennox-Gastaut syndrome


Seizures: All patients with LGS experience multiple types of seizures that are often difficult to control. Seizures typically arise in early childhood and can occur as frequently as multiple times a day.

Cognitive Impairment: Most patients with LGS experience some degree of cognitive impairment that becomes more apparent after seizures begin.


  • Behavior problems
  • Feeding problems
  • Sleep problems
  • Movement problems

How is Lennox-Gastaut syndrome diagnosed?

A diagnosis of LGS is made when multiple seizure types, a slow spike-and-wave EEG pattern, and cognitive impairment are present. Some patients are diagnosed with LGS and another genetic epilepsy.

How is Lennox-Gastaut syndrome treated?

Currently there is no cure for LGS. Patients are treated for their symptoms, not for the underlying cause of the disease. Seizure control is the primary goal for patients with LGS. There are currently companies investigating treatments for LGS and researchers analyzing patient data to better understand the condition and all potential causes so a cure may be found.

AmbitCare can help you understand how rare disease might be part of your story.

The average person with a rare disease sees 7.3 specialists over a span of 5-7 years before receiving an accurate diagnosis. AmbitCare Ambassadors provide free services including listening to understand your challenges, guiding you on potential next steps, and recommending resources.

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Have additional questions? Contact an AmbitCare Ambassador by phone at 1-877-584-8995 or by email at today.

Our hours of operation are Monday-Friday, 9-5pm ET. An AmbitCare Ambassador will typically respond within 1-2 business days.

* Please note that while AmbitCare Ambassadors can help you better understand what resources are available for families with loved ones suffering from seizures and developmental delays, they are not licensed medical providers and thus can neither diagnose any disease or disorder nor endorse or recommend any specific medical treatments.